Posts - Posada Lab

We are hiring a lab tech!

We are looking for a full-time laboratory technician. Offer 1023-109593 (in Spanish and English) at https://secretaria.uvigo.gal/uv/web/convocatoria/public/show/1150. Open until June 6.…

SIEVE: joint inference of single‑nucleotide
variants and cell phylogeny from single‑cell
DNA sequencing data

A very nice collaboration with the Szczurek and Beerenwinkel labs under the Computational ONcology TRaining Alliance Innovative Training (CONTRA) Network.…

Genomic characterization of circulating tumor cells

Today out in Genomics! We found substantial differences in the mutational loads of CTC pools obtained using different CTC-capture methods.…

On the root of eukaryotes

We started this collaboration with the Katz lab and today is finally out! Using phylogenomics, we propose that the eukaryote…

Scalable single-cell phylogenies

Nice collaboration with Luay Nakhleh and Hamim Zafar labs on scalable single-cell phylogenetic inference: Phylovar: toward scalable phylogeny-aware inference of…

mini-review on single-cell DNA variant callers

https://doi.org/10.1016/j.csbj.2022.06.013 Here, we review current approaches for single-cell variant calling, emphasizing single nucleotide variants. We highlight their potential benefits and shortcomings…

phylogenetic origins of relapse using single-cell data

Our phylogenetic analysis of single cells exposes how, where and when malignant cells survive treatment in a personalized manner in…

mtDNA single-cell paper

In CRC, mtDNA heteroplasmy mainly arises from differences among cells, but in some cases, the ancestral tumor cell can host…

Understanding SARS-CoV-2 transmission

Together with colleagues at a local hospital, here we show that is not easy to figure out with just genomics…

CellPhy paper

Finally out! ML inference of single-cell phylogenies https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02583-w Download CellPhy at: https://github.com/amkozlov/cellphy