Our phylogenetic analysis of single cells exposes how, where and when malignant cells survive treatment in a personalized manner in a liver relapse of a CRC metastasis. We show that the relapse originated from the expansion of a single metastatic lineage that slowly evolved in the liver. Interestingly, there is a clear contribution of chemotherapy exposure to the overall mutational burden of the relapse
https://www.sciencedirect.com/science/article/pii/S0304383522002518
