In CRC, mtDNA heteroplasmy mainly arises from differences among cells, but in some cases, the ancestral tumor cell can host distinct mtDNA molecules: Single-cell mtDNA heteroplasmy in colorectal cancer
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New paper: Detecting changes in the evolutionary rate of cell lineages
Check our new paper on changes in the evolutionary rate among somatic lineages! https://cell.com/cell-genomics/fulltext/S2666-979X(23)00177-5… Here, we developed a novel phylogenetic…
Continue ReadingSIEVE: joint inference of single‑nucleotide
variants and cell phylogeny from single‑cell
DNA sequencing data
A very nice collaboration with the Szczurek and Beerenwinkel labs under the Computational ONcology TRaining Alliance Innovative Training (CONTRA) Network.…
Continue ReadingGenomic characterization of circulating tumor cells
Today out in Genomics! We found substantial differences in the mutational loads of CTC pools obtained using different CTC-capture methods.CTC…
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