Check our new paper on changes in the evolutionary rate among somatic lineages!
https://cell.com/cell-genomics/fulltext/S2666-979X(23)00177-5…
Here, we developed a novel phylogenetic test for varying evolutionary rates in scDNA-seq data. We rejected a constant rate in most cancer and half of the healthy datasets analyzed. Mutations in driver genes in cancer datasets could explain the rate acceleration of several lineages.
