A very nice collaboration with the Szczurek and Beerenwinkel labs under the Computational ONcology TRaining Alliance Innovative Training (CONTRA) Network.

Here we present SIEVE, a statistical method for the joint inference of somatic variants and
cell phylogeny from single-cell DNA sequencing. In our simulations, SIEVE outperforms other methods in phylogenetic
reconstruction and variant calling accuracy, especially in the inference of homozygous


Overview of the SIEVE model